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Rigel to Present at the 2005 FASEB Summer Research Conference

SOUTH SAN FRANCISCO, Calif. - July 22, 2005

Rigel Pharmaceuticals, Inc. (Nasdaq: RIGL) today announced that Esteban Masuda, Ph.D., director of Immunology, will present at the 2005 Federation of American Societies for Experimental Biology (FASEB) Summer Research Conference on Immunoreceptors, being held July 23-28 at the Omni Tucson National Golf Resort & Spa in Tucson, Arizona.

Dr. Masuda’s talk, “R406, a Potent and Selective Syk Kinase Inhibitor for the Treatment of Rheumatoid Arthritis,” will take place at 4:10 p.m. on Monday, July 25th.

About Rigel (www.rigel.com)
Rigel's mission is to become a source of novel, small-molecule drugs to meet large, unmet medical needs. We have three product development programs: asthma/allergy, rheumatoid arthritis and cancer. Our strategy is to commence clinical trials with one lead compound each year and to develop a portfolio of product candidates for our own proprietary programs and with potential collaborative partners.

This press release contains "forward-looking" statements, including statements related to Rigel's plans to pursue clinical development of product candidates and the timing thereof and the potential efficacy of product candidates. Any statements contained in this press release that are not statements of historical fact may be deemed to be forward-looking statements. Words such as "plans," "intends," "expects" and similar expressions are intended to identify these forward-looking statements. There are a number of important factors that could cause Rigel's results to differ materially from those indicated by these forward-looking statements, including risks associated with the timing and success of pre-clinical studies and clinical trials, as well as other risks detailed from time to time in Rigel's SEC reports, including its Quarterly Report on Form 10-Q for the quarter ended March 31, 2005. Rigel does not undertake any obligation to update forward-looking statements.

Contact: Raul R. Rodriguez
Phone: 650.624.1302
Email: invrel@rigel.com


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