-------------------------- OMB APPROVAL -------------------------- OMB Number: 3235-0145 Expires: August 31, 1999 Estimated average burden hours per response...14.90 -------------------------- UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G UNDER THE SECURITIES EXCHANGE ACT OF 1934 (AMENDMENT NO. _________)* Rigel Pharmaceuticals, Inc. ------------------------------------------------------ (Name of Issuer) COMMON STOCK, $.001 par value ------------------------------------------------------ (Title of Class of Securities) 766559 10 8 ------------------------------------------------------ (CUSIP Number) December 31, 2000 ------------------------------------------------------ (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the rule pursuant to which this Schedule is filed: [ ] Rule 13d-1(b) [ ] Rule 13d-1(c) [X] Rule 13d-1(d) *The remainder of this cover page shall be filled out for a reporting person's initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page. The information required in the remainder of this cover page shall not be deemed to be "filed" for the purpose of Section 18 of the Securities Exchange Act of 1934 ("Act") or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes). Page 1 of 11 pages - -------------------------------------- ------------------------------------ CUSIP No. 766559 10 8 13G Page 2 of 11 Pages - -------------------------------------- ------------------------------------ - -------------------------------------------------------------------------------------------------------------- 1 NAMES OF REPORTING PERSONS I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY) Frazier Healthcare II, L.P. - -------------------------------------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS) (a) [ ] (b) [ ] - -------------------------------------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION Organized under the laws of the State of Delaware - -------------------------------------------------------------------------------------------------------------- 5 SOLE VOTING POWER 0 shares NUMBER OF ---------------------------------------------------------------------------------------- SHARES 6 SHARED VOTING POWER BENEFICIALLY OWNED BY 4,332,575 shares EACH ---------------------------------------------------------------------------------------- REPORTING 7 SOLE DISPOSITIVE POWER PERSON WITH: 0 shares --------------------------------------------------------------------------------------- 8 SHARED DISPOSITIVE POWER 4,332,575 shares - -------------------------------------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 4,332,575 shares - -------------------------------------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS) [ ] - -------------------------------------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 12.1% - -------------------------------------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON (SEE INSTRUCTIONS) PN - -------------------------------------------------------------------------------------------------------------- Page 2 of 11 pages
- -------------------------------------- ------------------------------------ CUSIP No. 766559 10 8 13G Page 3 of 11 Pages - -------------------------------------- ------------------------------------ - -------------------------------------------------------------------------------------------------------------- 1 NAMES OF REPORTING PERSONS I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY) FHM II, L.L.C. - -------------------------------------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS) (a) [ ] (b) [ ] - -------------------------------------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION Organized under the laws of the State of Delaware - -------------------------------------------------------------------------------------------------------------- 5 SOLE VOTING POWER 0 shares NUMBER OF ---------------------------------------------------------------------------------------- SHARES 6 SHARED VOTING POWER BENEFICIALLY OWNED BY 4,332,575 shares EACH ---------------------------------------------------------------------------------------- REPORTING 7 SOLE DISPOSITIVE POWER PERSON WITH: 0 shares --------------------------------------------------------------------------------------- 8 SHARED DISPOSITIVE POWER 4,332,575 shares - -------------------------------------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 4,332,575 shares - -------------------------------------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS) [ ] - -------------------------------------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 12.1% - -------------------------------------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON (SEE INSTRUCTIONS) OO - -------------------------------------------------------------------------------------------------------------- Page 3 of 11 pages
- -------------------------------------- ------------------------------------ CUSIP No. 766559 10 8 13G Page 4 of 11 Pages - -------------------------------------- ------------------------------------ - -------------------------------------------------------------------------------------------------------------- 1 NAMES OF REPORTING PERSONS I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY) Frazier Management, L.L.C. - -------------------------------------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS) (a) [ ] (b) [ ] - -------------------------------------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION Organized under the laws of the State of Delaware - -------------------------------------------------------------------------------------------------------------- 5 SOLE VOTING POWER 0 shares NUMBER OF ---------------------------------------------------------------------------------------- SHARES 6 SHARED VOTING POWER BENEFICIALLY OWNED BY 4,332,575 shares EACH ---------------------------------------------------------------------------------------- REPORTING 7 SOLE DISPOSITIVE POWER PERSON WITH: 0 shares --------------------------------------------------------------------------------------- 8 SHARED DISPOSITIVE POWER 4,332,575 shares - -------------------------------------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 4,332,575 shares - -------------------------------------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS) [ ] - -------------------------------------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 12.1% - -------------------------------------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON (SEE INSTRUCTIONS) OO - -------------------------------------------------------------------------------------------------------------- Page 4 of 11 pages
- -------------------------------------- ------------------------------------ CUSIP No. 766559 10 8 13G Page 5 of 11 Pages - -------------------------------------- ------------------------------------ - -------------------------------------------------------------------------------------------------------------- 1 NAMES OF REPORTING PERSONS I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY) Frazier & Company, Inc. - -------------------------------------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS) (a) [ ] (b) [ ] - -------------------------------------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION Organized under the laws of the State of Washington - -------------------------------------------------------------------------------------------------------------- 5 SOLE VOTING POWER 0 shares NUMBER OF ---------------------------------------------------------------------------------------- SHARES 6 SHARED VOTING POWER BENEFICIALLY OWNED BY 4,347,719 shares EACH ---------------------------------------------------------------------------------------- REPORTING 7 SOLE DISPOSITIVE POWER PERSON WITH: 0 shares --------------------------------------------------------------------------------------- 8 SHARED DISPOSITIVE POWER 4,347,719 shares - -------------------------------------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 4,347,719 shares - -------------------------------------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS) [ ] - -------------------------------------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 12.1% - -------------------------------------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON (SEE INSTRUCTIONS) CO - -------------------------------------------------------------------------------------------------------------- Page 5 of 11 pages
- -------------------------------------- ------------------------------------ CUSIP No. 766559 10 8 13G Page 6 of 11 Pages - -------------------------------------- ------------------------------------ - -------------------------------------------------------------------------------------------------------------- 1 NAMES OF REPORTING PERSONS I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY) Alan D. Frazier - -------------------------------------------------------------------------------------------------------------- 2 CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS) (a) [ ] (b) [ ] - -------------------------------------------------------------------------------------------------------------- 3 SEC USE ONLY - -------------------------------------------------------------------------------------------------------------- 4 CITIZENSHIP OR PLACE OF ORGANIZATION United States - -------------------------------------------------------------------------------------------------------------- 5 SOLE VOTING POWER 0 shares NUMBER OF ---------------------------------------------------------------------------------------- SHARES 6 SHARED VOTING POWER BENEFICIALLY OWNED BY 4,347,719 shares EACH ---------------------------------------------------------------------------------------- REPORTING 7 SOLE DISPOSITIVE POWER PERSON WITH: 0 shares --------------------------------------------------------------------------------------- 8 SHARED DISPOSITIVE POWER 4,347,719 shares - -------------------------------------------------------------------------------------------------------------- 9 AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON 4,347,719 shares - -------------------------------------------------------------------------------------------------------------- 10 CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS) [ ] - -------------------------------------------------------------------------------------------------------------- 11 PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 12.1% - -------------------------------------------------------------------------------------------------------------- 12 TYPE OF REPORTING PERSON (SEE INSTRUCTIONS) IN - -------------------------------------------------------------------------------------------------------------- Page 6 of 11 pages
- -------------------------------------- ------------------------------------ CUSIP No. 766559 10 8 13G Page 7 of 11 Pages - -------------------------------------- ------------------------------------ Schedule 13G Item 1(a). Name of Issuer: Rigel Pharmaceuticals, Inc. Item 1(b). Address of Issuer's Principal Executive Offices: 240 East Grand Avenue, South San Francisco, California 94080 Item 2(a). Names of Persons Filing: Frazier Healthcare II, L.P., FHM II, L.L.C., Frazier Management, L.L.C., Frazier & Company, Inc. and Alan D. Frazier. The sole general partner of Frazier Healthcare II, L.P. is FHM II, L.L.C., whose managing member is Frazier Management, L.L.C. The managing member of Frazier Management, L.L.C. is Frazier & Company, Inc. The sole shareholder of Frazier & Company, Inc. is Alan D. Frazier. Item 2(b). Address of Principal Business Office or, if None, Residence: The address of the principal business office of Frazier Healthcare II, L.P., FHM II, L.L.C., Frazier Management, L.L.C., Frazier & Company, Inc. and Alan D. Frazier is 601 Union Street, Suite 3300, Seattle, WA 98101. Item 2(c). Citizenship: Frazier Healthcare II, L.P. is a limited partnership organized under the laws of the State of Delaware. FHM II, L.L.C. and Frazier Management, L.L.C. are each a limited liability company organized under the laws of the State of Delaware. Frazier & Company, Inc. is a corporation organized under the laws of the State of Washington. Alan D. Frazier is a citizen of the United States. Item 2(d). Title of Class of Securities: Common Stock, $.001 par value. Item 2(e). CUSIP Number: 766559 10 8 Item 3. If this statement is filed pursuant to Rules 13d-1(b), or 13d-2(b) or (c), check whether the person filing is a: Not Applicable. Item 4. Ownership. The following describes the ownership of Common Stock by Frazier Healthcare II, L.P., FHM II, L.L.C. and Frazier Management, L.L.C. as of December 31, 2000: (a) Amount Beneficially Owned: As of December 31, 2000, Frazier Healthcare II, L.P. was the record owner of 4,332,575 shares of Common Stock. As the sole general partner of Frazier Healthcare II, L.P., FHM II, L.L.C. may be deemed to own beneficially 4,332,575 shares. As the managing member of FHM II, L.L.C., Frazier Management, L.L.C. may also be deemed to own beneficially 4,332,575 shares. Page 7 of 11 pages
- -------------------------------------- ------------------------------------ CUSIP No. 766559 10 8 13G Page 8 of 11 Pages - -------------------------------------- ------------------------------------ (b) Percent of Class: Frazier Healthcare II, L.P. 12.1% FHM II, L.L.C. 12.1% Frazier Management, L.L.C. 12.1% The foregoing percentages are calculated based on 35,946,056 shares of Common Stock of the Issuer expected to be outstanding after the initial public offering of the Issuer as reported in the Issuer's prospectus filed with the Securities and Exchange Commission on November 29, 2000 pursuant to Rule 424(b)(4). (c) Number of shares as to which such person has: (i) Sole power to vote of direct the vote: 0 (ii) Shared power to vote or to direct the vote: 4,332,575 (iii) Sole power to dispose or to direct the disposition of: 0 (iv) Shared power to dispose or to direct the disposition of: 4,332,575 Each of such persons denies beneficial ownership of such shares of Common Stock except for those shares, if any, such person holds of record. The following describes the ownership of Common Stock by Frazier & Company, Inc. and Alan D. Frazier: (a) Amount Beneficially Owned: As of December 31, 2000, Frazier Healthcare II, L.P. was the record owner of 4,332,575 shares of Common Stock and Frazier & Company, Inc. was the record owner of 15,144 shares of Common Stock. As the managing member of Frazier Management, L.L.C., which is the managing member of FHM II, L.L.C., which is the sole general partner of Frazier Healthcare II, L.P., Frazier & Company, Inc. may be deemed to own beneficially 4,347,719 shares. As the sole shareholder of Frazier & Company, Inc., Alan D. Frazier may also be deemed to own beneficially 4,347,719 shares. (b) Percent of Class: Frazier & Company, Inc. 12.1% Alan D. Frazier 12.1% The foregoing percentages are calculated based on 35,946,056 shares of Common Stock of the Issuer expected to be outstanding after the initial public offering of the Issuer as reported in the Issuer's prospectus filed with the Securities and Exchange Commission on November 29, 2000 pursuant to Rule 424(b)(4). (c) Number of shares as to which such person has: (i) Sole power to vote of direct the vote: 0 (ii) Shared power to vote or to direct the vote: 4,347,719 Page 8 of 11 pages
- -------------------------------------- ------------------------------------ CUSIP No. 766559 10 8 13G Page 9 of 11 Pages - -------------------------------------- ------------------------------------ (iii) Sole power to dispose or to direct the disposition of: 0 (iv) Shared power to dispose or to direct the disposition of: 4,347,719 Each of such persons denies beneficial ownership of such shares of Common Stock except for those shares, if any, such person holds of record. Item 5. Ownership of Five Percent or Less of a Class. Not Applicable. Item 6. Ownership of More than Five Percent on Behalf of Another Person. Not Applicable. Item 7. Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on by the Parent Holding Company. Not Applicable. Item 8. Identification and Classification of Members of the Group. Not Applicable. The reporting persons expressly disclaim membership in a "group" as defined in Rule 13d-1(b)(1)(ii)(J). Item 9. Notice of Dissolution of Group. Not Applicable. Item 10. Certifications. Not Applicable. This statement on Schedule 13G is not filed pursuant to Rule 13d-1(b) or Rule 13d-1(c). [REMAINDER OF PAGE LEFT BLANK INTENTIONALLY] [SIGNATURE PAGE FOLLOWS IMMEDIATELY] Page 9 of 11 pages
- -------------------------------------- ------------------------------------ CUSIP No. 766559 10 8 13G Page 10 of 11 Pages - -------------------------------------- ------------------------------------ Signatures After reasonable inquiry and to the best of his knowledge and belief, each of the undersigned certifies that the information set forth in this statement is true, complete and correct. Each of the undersigned also hereby agrees to file this statement jointly pursuant to the Agreement listed on Exhibit 1 hereto. Dated: February 7, 2001 FRAZIER HEALTHCARE II, L.P. By: FHM II, L.L.C. Its General Partner By: Frazier Management, L.L.C. Its Managing Member By: Frazier & Company, Inc. Its Managing Member By: /s/ Alan D. Frazier ---------------------- Alan D. Frazier, President FHM II. L.L.C. By: Frazier Management, L.L.C. Its Managing Member By: Frazier & Company, Inc. Its Managing Member By: /s/ Alan D. Frazier ---------------------- Alan D. Frazier, President FRAZIER MANAGEMENT, L.L.C. By: Frazier & Company, Inc. Its Managing Member By: /s/ Alan D. Frazier ---------------------- Alan D. Frazier, President FRAZIER & COMPANY, INC. By:/s/ Alan D. Frazier Alan D. Frazier, President, Director and Shareholder /s/ Alan D. Frazier ------------------- Alan D. Frazier Page 10 of 11 pages