EXHIBIT 23.1 CONSENT OF ERNST & YOUNG LLP, INDEPENDENT AUDITORS We consent to the reference to our firm under the captions "Selected Financial Data" and "Experts" and to the use of our report dated February 25, 2000, in Amendment No. 4 to the Registration Statement (Form S-1 No. 333-45864) and related Prospectus of Rigel Pharmaceuticals, Inc. for the registration of 5,750,000 shares of its common stock. /s/ ERNST & YOUNG LLP Palo Alto, California November 17, 2000