EXHIBIT A Agreement of Joint Filing Pursuant to Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, the undersigned hereby agree that only one statement containing the information required by Schedule 13D need be filed with respect to the ownership by each of the undersigned of shares of stock of Rigel Pharmaceuticals, Inc. Dated: May 8, 2003 MPM BIOVENTURES III, L.P. MPM BIOVENTURES III-QP, L.P. By: MPM BioVentures III GP, L.P., By: MPM BioVentures III GP, L.P., its General Partner its General Partner By: MPM BioVentures III LLC, By: MPM BioVentures III LLC, its General Partner its General Partner By: /s/ Luke Evnin By: /s/ Luke Evnin ---------------------------------- ---------------------------------- Name: Luke Evnin Name: Luke Evnin Title: Series A Member Title Series A Member MPM BIOVENTURES III GMBH & CO. MPM BIOVENTURES III PARALLEL BETEILIGUNGS KG FUND, L.P. By: MPM BioVentures III GP, L.P., in its By: MPM BioVentures III GP, L.P., capacity as the Managing Limited its General Partner Partner By: MPM BioVentures III LLC, By: MPM BioVentures III LLC, its General Partner its General Partner By: /s/ Luke Evnin By: /s/ Luke Evnin ---------------------------------- --------------------------------- Name: Luke Evnin Name: Luke Evnin Title: Series A Member Title: Series A Member MPM ASSET MANAGEMENT MPM BIOVENTURES III GP, L.P. INVESTORS 2003 BVIII LLC By: MPM BioVentures III LLC, its General Partner By: /s/ Luke Evnin By: /s/ Luke Evnin ---------------------------------- --------------------------------- Name: Luke Evnin Name: Luke Evnin Title: Series A Member Title Series A Member
MPM BIOVENTURES III LLC MPM BIOEQUITIES MASTER FUND, L.P. By: /s/ Luke Evnin By: MPM BioEquities GP, L.P., ---------------------------------- its General Partner Name: Luke Evnin By: MPM BioEquities GP LLC, Title: Manager its General Partner By: /s/ Luke Evnin --------------------------------- Name: Luke Evnin Title: Series A Member MPM BIOEQUITIES GP, L.P. MPM BIOEQUITIES GP, LLC By: MPM BioEquities GP, LLC By: /s/ Luke Evnin its General Partner --------------------------------- Name: Luke Evnin Title: Manager By: /s/ Luke Evnin ---------------------------------- Name: Luke Evnin Title: Manager By: /s/ Luke Evnin By: /s/ Ansbert Gadicke ---------------------------------- --------------------------------- Name: Luke Evnin Name: Ansbert Gadicke By: /s/ Nicholas Galakatos By: /s/ Dennis Henner ---------------------------------- --------------------------------- Name: Nicholas Galakatos Name: Dennis Henner By: /s/ Robert Liptak By: /s/ Nick Simon, III ---------------------------------- --------------------------------- Name: Robert Liptak Name: Nick Simon, III By: /s/ Michael Steinmetz By: /s/ Kurt von Emster ---------------------------------- --------------------------------- Name: Michael Steinmetz Name: Kurt von Emster By: /s/ Kurt Wheeler ---------------------------------- Name: Kurt Wheeler