Annual report pursuant to Section 13 and 15(d)

PROPERTY AND EQUIPMENT (Details)

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PROPERTY AND EQUIPMENT (Details) - USD ($)
12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
PROPERTY AND EQUIPMENT      
Total property and equipment $ 13,153,000 $ 19,948,000  
Less accumulated depreciation and amortization (12,278,000) (18,792,000)  
Property and equipment, net 875,000 1,156,000  
Assets disposed 7,000,000 618,000  
Depreciation and amortization 465,000 941,000 $ 1,439,000
Restructuring, asset impairment charges 319,000 319,000  
Laboratory equipment      
PROPERTY AND EQUIPMENT      
Total property and equipment 11,122,000 17,986,000  
Computer and software      
PROPERTY AND EQUIPMENT      
Total property and equipment 1,320,000 1,280,000  
Furniture and equipment      
PROPERTY AND EQUIPMENT      
Total property and equipment $ 711,000 $ 682,000