Annual report [Section 13 and 15(d), not S-K Item 405]

SPONSORED RESEARCH AND LICENSE AGREEMENTS AND GOVERNMENT CONTRACTS (Details)

v3.25.4
SPONSORED RESEARCH AND LICENSE AGREEMENTS AND GOVERNMENT CONTRACTS (Details)
1 Months Ended 6 Months Ended 12 Months Ended
Nov. 30, 2024
USD ($)
Sep. 30, 2024
USD ($)
Jan. 31, 2024
USD ($)
May 31, 2022
USD ($)
Apr. 30, 2022
USD ($)
Apr. 30, 2021
USD ($)
Feb. 29, 2020
USD ($)
Jan. 31, 2019
USD ($)
Oct. 31, 2018
USD ($)
Apr. 01, 2024
USD ($)
Dec. 31, 2025
USD ($)
period
Dec. 31, 2024
USD ($)
Dec. 31, 2023
USD ($)
Dec. 31, 2021
USD ($)
Jan. 31, 2025
USD ($)
Dec. 31, 2022
USD ($)
Oct. 31, 2019
USD ($)
Collaborations                                  
Upfront payment           $ 125,000,000.0                      
Right to opt out of agreement, different specified times | period                     2            
Payment of cost share to collaboration partner                     $ 0 $ 3,605,000 $ 2,632,000        
Release of cost share liability                     39,981,000 0 0        
Cost of product sales                     19,621,000 18,647,000 7,110,000        
Accounts receivable                     51,763,000 41,615,000          
Revenue from contract with customer, excluding assessed tax                     294,282,000 179,278,000 116,882,000        
Deferred revenue                     $ 1,355,000 1,355,000          
Maximum                                  
Collaborations                                  
Collaborative arrangement potential payment percent   30.00%                              
Minimum                                  
Collaborations                                  
Collaborative arrangement potential payment percent   20.00%                              
ocadusertib                                  
Collaborations                                  
Company's percentage of development costs                     20.00%            
Financing component liability                     $ 57,900,000            
Financing liability interest accretion discount rate (in percent)                     6.40%            
Revenue, remaining performance obligation                               $ 67,100,000  
Contract with customer, liability                     $ 0 0          
ocadusertib | Maximum                                  
Collaborations                                  
Funding commitment                   $ 65,000,000.0 65,000,000.0            
Non-CNS penetrant IP                                  
Collaborations                                  
Revenue recognized                           $ 60,400,000      
fostamatinib                                  
Collaborations                                  
Government contracts revenue                     $ 300,000 0 1,100,000        
Government Assistance, Operating Income, Increase (Decrease), Statement of Income or Comprehensive Income [Extensible Enumeration]                     Revenue from contract with customer, excluding assessed tax            
Rezlidhia                                  
Collaborations                                  
Company's percentage of development costs   50.00%                              
Grifols                                  
Collaborations                                  
Upfront payment               $ 30,000,000.0                  
Contract with customer, liability                     $ 0 0          
Grifols | fostamatinib                                  
Collaborations                                  
Collaborative payment received             $ 20,000,000.0                    
Grifols | fostamatinib | Maximum                                  
Collaborations                                  
Royalty payment as a percentage of net sales               30.00%                  
Grifols | Royalty                                  
Collaborations                                  
Revenue recognized                     7,200,000 5,100,000 3,200,000        
Kissei                                  
Collaborations                                  
Contingent payments due to collaborative agreements                 $ 115,000,000.0                
Upfront payment                 $ 33,000,000.0                
Collaborative arrangement payment percent                 20.00%                
Revenue from contract with customer, excluding assessed tax                     4,200,000 10,400,000 2,200,000        
Kissei | fostamatinib                                  
Collaborations                                  
Contract with customer, liability                     1,400,000 1,400,000     $ 3,000,000.0    
Collaborative payment received         $ 5,000,000.0                        
Accounts receivable                               20,000,000.0  
Kissei | Rezlidhia                                  
Collaborations                                  
Upfront payment   $ 10,000,000.0                              
Revenue recognized   10,000,000.0                              
Potential payments   152,500,000                              
Company's share of development costs, limit   $ 3,000,000.0                              
Forma | Sublicense revenue fee                                  
Collaborations                                  
Cost of product sales                       2,300,000          
Medison                                  
Collaborations                                  
Contract with customer, liability                     0 0          
Medison | fostamatinib                                  
Collaborations                                  
Revenue recognized                     1,100,000 500,000 500,000        
Medison | fostamatinib | Product Financing Arrangement                                  
Collaborations                                  
Contract with customer, liability                                 $ 5,000,000.0
Knight                                  
Collaborations                                  
Revenue recognized                     0 0 0        
Deferred revenue                     0 0          
Dr. Reddy's                                  
Collaborations                                  
Upfront payment $ 4,000,000.0                                
Revenue recognized                     100,000            
Potential payments $ 36,000,000.0                                
Collaborative arrangement payment percent 30.00%                                
Dr. Reddy's | fostamatinib                                  
Collaborations                                  
Upfront payment                       4,000,000.0          
Dr. Reddy's | Sublicense revenue fee                                  
Collaborations                                  
Cost of product sales                       900,000          
Development and regulatory milestones by non-CNS disease products                                  
Collaborations                                  
Contingent payments due to collaborative agreements                     330,000,000.0            
Product-by-product Sales Milestone                                  
Collaborations                                  
Contingent payments due to collaborative agreements                     100,000,000.0            
Development and regulatory milestones by CNS disease products                                  
Collaborations                                  
Contingent payments due to collaborative agreements                     256,000,000.0            
Central Nervous System, Product-by-product Sales Milestone                                  
Collaborations                                  
Contingent payments due to collaborative agreements                     150,000,000.0            
Licensed Rights | Non-CNS penetrant IP                                  
Collaborations                                  
Revenue, remaining performance obligation                               $ 6,700,000  
Commercial Milestones | Grifols                                  
Collaborations                                  
Contingent payments due to collaborative agreements               $ 297,500,000                  
Upon EMA approval of fostamatinib for treatment of chronic ITP | Grifols | fostamatinib                                  
Collaborations                                  
Collaborative payment received             17,500,000                    
Creditable advance royalty payment | Grifols | fostamatinib                                  
Collaborations                                  
Collaborative payment received             $ 2,500,000                    
Delivery of drug supply for commercialization | Grifols                                  
Collaborations                                  
Revenue recognized                     6,100,000 4,000,000.0 5,600,000        
Collaborative Arrangement                                  
Collaborations                                  
Contingent payments due to collaborative agreements                     1,100,000,000            
Collaborative Arrangement | Specified Development Events                                  
Collaborations                                  
Contingent payments due to collaborative agreements                     179,500,000            
Collaborative Arrangement | Specified Regulatory Events                                  
Collaborations                                  
Contingent payments due to collaborative agreements                     270,600,000            
Collaborative Arrangement | Specified Product Launch Events                                  
Collaborations                                  
Contingent payments due to collaborative agreements                     $ 637,000,000.0            
Amended Lilly Agreement | ocadusertib                                  
Collaborations                                  
Funding commitment                       $ 40,000,000.0          
Agreement opt-out right, exercise period                     30 days            
Payment of cost share to collaboration partner                   $ 21,400,000              
Commercial and license agreements | Knight                                  
Collaborations                                  
Upfront payment       $ 2,000,000.0                          
Commercial and license agreements | Knight | Maximum                                  
Collaborations                                  
Contingent payments due to collaborative agreements       $ 20,000,000.0                          
Collaborative arrangement payment percent       30.00%                          
Commercial and license agreements | Knight | Minimum                                  
Collaborations                                  
Collaborative arrangement payment percent       20.00%                          
Strategic collaboration agreement with MD Anderson | Rezlidhia                                  
Collaborations                                  
Payment of cost share to collaboration partner                     $ 5,300,000            
Amount due to collaboration partner                         $ 15,000,000.0        
Collaboration period                     5 years            
Strategic collaboration agreement with CONNECT | Rezlidhia                                  
Collaborations                                  
Amount due to collaboration partner     $ 3,000,000.0                            
Collaboration period     4 years