Annual report pursuant to Section 13 and 15(d)

STOCK-BASED COMPENSATION - Employee Stock Option Plans (Details)

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STOCK-BASED COMPENSATION - Employee Stock Option Plans (Details)
12 Months Ended
Dec. 31, 2017
plan
shares
STOCK-BASED COMPENSATION  
Number of stock option plans | plan 4
Number of shares of common stock authorized (in shares) 32,104,836
Employee stock option  
STOCK-BASED COMPENSATION  
Expiration period 10 years
Options exercised during the period (in shares) 1,161,093
Equity incentive plan 2011 | Employee stock option  
STOCK-BASED COMPENSATION  
Number of shares of common stock authorized (in shares) 16,174,599
Equity incentive plan 2011 | Employee stock option | Minimum  
STOCK-BASED COMPENSATION  
Vesting period 0 years
Equity incentive plan 2011 | Employee stock option | Maximum  
STOCK-BASED COMPENSATION  
Vesting period 5 years
Equity incentive plan 2000 | Employee stock option  
STOCK-BASED COMPENSATION  
Number of shares of common stock authorized (in shares) 12,142,055
Equity incentive plan 2000 | Employee stock option | Minimum  
STOCK-BASED COMPENSATION  
Vesting period 0 years
Equity incentive plan 2000 | Employee stock option | Maximum  
STOCK-BASED COMPENSATION  
Vesting period 5 years
Non-employee directors stock option plan 2000 | Employee stock option  
STOCK-BASED COMPENSATION  
Number of shares of common stock authorized (in shares) 1,988,182
Non-employee directors stock option plan 2000 | Employee stock option | Maximum  
STOCK-BASED COMPENSATION  
Expiration period 10 years
Inducement Plan  
STOCK-BASED COMPENSATION  
Number of shares of common stock authorized (in shares) 1,800,000