Annual report pursuant to Section 13 and 15(d)

STATEMENTS OF OPERATIONS

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STATEMENTS OF OPERATIONS (USD $)
In Thousands, except Per Share data, unless otherwise specified
12 Months Ended
Dec. 31, 2011
Dec. 31, 2010
Dec. 31, 2009
Contract revenues from collaborations $ 4,750 $ 125,000 $ 750
Costs and expenses:      
Research and development 69,350 64,392 90,743
General and administrative 21,768 25,291 20,903
Restructuring charges 0 0 1,141
Total costs and expenses 91,118 89,683 112,787
Income (loss) from operations (86,368) 35,317 (112,037)
Other income 0 2,361 0
Interest income 420 303 600
Interest expense (25) (91) (203)
Income (loss) before income taxes (85,973) 37,890 (111,640)
Income tax benefit 0 0 93
Net income (loss) $ (85,973) $ 37,890 $ (111,547)
Net income (loss) per share:      
Basic (in dollars per share) $ (1.36) $ 0.73 $ (2.73)
Diluted (in dollars per share) $ (1.36) $ 0.72 $ (2.73)
Weighted average shares used in computing net income (loss) per share:      
Basic (in shares) 63,329 52,055 40,876
Diluted (in shares) 63,329 52,573 40,876