| Schedule of stock-based compensation expense related to all of the entity's stock-based awards |
Total stock-based compensation expense related to all of our stock-based awards was as follows (in thousands):
|
|
|
Year Ended December 31,
|
|
|
|
|
2014
|
|
2013
|
|
2012
|
|
|
Research and development
|
|
$
|
4,674
|
|
$
|
3,930
|
|
$
|
7,050
|
|
|
General and administrative
|
|
|
5,113
|
|
|
2,997
|
|
|
5,567
|
|
|
Restructuring charges
|
|
|
—
|
|
|
239
|
|
|
—
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Total stock-based compensation expense
|
|
$
|
9,787
|
|
$
|
7,166
|
|
$
|
12,617
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
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|
|
|
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|
| Schedule of option activity under equity incentive plans |
|
|
|
Shares
Available
For Grant
|
|
Number of
Shares
Underlying
Options
|
|
Weighted-
Average
Exercise Price
|
|
Weighted-
Average
Remaining
Contractual
Term
(in years)
|
|
Aggregate
Intrinsic
Value
|
|
|
Outstanding at January 1, 2012
|
|
|
4,707,753
|
|
|
11,749,359
|
|
$
|
12.07
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authorized for grant
|
|
|
600,000
|
|
|
—
|
|
|
|
|
|
|
|
|
|
|
|
Granted
|
|
|
(2,149,266
|
)
|
|
2,149,266
|
|
$
|
8.13
|
|
|
|
|
|
|
|
|
Exercised
|
|
|
—
|
|
|
(254,149
|
)
|
$
|
7.08
|
|
|
|
|
|
|
|
|
Cancelled
|
|
|
40,099
|
|
|
(40,099
|
)
|
$
|
19.60
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Outstanding at December 31, 2012
|
|
|
3,198,586
|
|
|
13,604,377
|
|
$
|
11.52
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authorized for grant
|
|
|
7,775,000
|
|
|
—
|
|
|
|
|
|
|
|
|
|
|
|
Granted
|
|
|
(3,140,956
|
)
|
|
3,140,956
|
|
$
|
5.46
|
|
|
|
|
|
|
|
|
Exercised
|
|
|
—
|
|
|
—
|
|
$
|
—
|
|
|
|
|
|
|
|
|
Cancelled
|
|
|
1,213,131
|
|
|
(1,213,131
|
)
|
$
|
8.26
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Outstanding at December 31, 2013
|
|
|
9,045,761
|
|
|
15,532,202
|
|
$
|
10.55
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Authorized for grant
|
|
|
—
|
|
|
—
|
|
|
|
|
|
|
|
|
|
|
|
Granted
|
|
|
(3,467,120
|
)
|
|
3,467,120
|
|
$
|
3.39
|
|
|
|
|
|
|
|
|
Exercised
|
|
|
—
|
|
|
(11,219
|
)
|
$
|
3.44
|
|
|
|
|
|
|
|
|
Cancelled
|
|
|
2,017,430
|
|
|
(2,017,430
|
)
|
$
|
10.75
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Outstanding at December 31, 2014
|
|
|
7,596,071
|
|
|
16,970,673
|
|
$
|
9.07
|
|
|
5.79
|
|
$
|
25,140
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Vested and expected to vest at December 31, 2014
|
|
|
|
|
|
16,861,378
|
|
$
|
9.10
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Exercisable at December 31, 2014
|
|
|
|
|
|
14,243,893
|
|
$
|
10.09
|
|
|
5.19
|
|
$
|
983
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Exercisable at December 31, 2013
|
|
|
|
|
|
13,246,612
|
|
$
|
11.44
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Exercisable at December 31, 2012
|
|
|
|
|
|
12,841,378
|
|
$
|
11.75
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
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|
|
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|
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|
| Schedule of stock options by exercise price |
Details of our stock options by exercise price are as follows as of December 31, 2014:
|
|
|
Options Outstanding
|
|
Options Exercisable
|
|
|
Exercise Price
|
|
Number of
Outstanding
Options
|
|
Weighted-
Average
Remaining
Contractual
Life
(in years)
|
|
Weighted-
Average
Exercise
Price
|
|
Number of
Options
|
|
Weighted-
Average
Exercise
Price
|
|
|
$1.68 - $3.55
|
|
|
2,317,779
|
|
|
8.77
|
|
$
|
3.29
|
|
|
1,112,849
|
|
$
|
3.36
|
|
|
$3.59 - $6.49
|
|
|
3,300,357
|
|
|
6.80
|
|
|
4.99
|
|
|
2,050,668
|
|
|
5.84
|
|
|
$6.51 - $6.55
|
|
|
2,207,938
|
|
|
7.53
|
|
|
6.52
|
|
|
1,991,664
|
|
|
6.52
|
|
|
$6.73 - $7.40
|
|
|
2,196,855
|
|
|
5.32
|
|
|
6.85
|
|
|
2,187,713
|
|
|
6.85
|
|
|
$7.53 - $8.27
|
|
|
2,132,765
|
|
|
6.42
|
|
|
8.11
|
|
|
2,091,925
|
|
|
8.11
|
|
|
$8.34 - $11.73
|
|
|
2,528,537
|
|
|
3.52
|
|
|
10.29
|
|
|
2,522,633
|
|
|
10.29
|
|
|
$15.49 - $24.56
|
|
|
1,132,244
|
|
|
0.96
|
|
|
23.41
|
|
|
1,132,244
|
|
|
23.41
|
|
|
$26.45
|
|
|
1,154,198
|
|
|
3.08
|
|
|
26.45
|
|
|
1,154,198
|
|
|
26.45
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
$1.68 - $26.45
|
|
|
16,970,673
|
|
|
5.79
|
|
|
9.07
|
|
|
14,243,894
|
|
$
|
10.09
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
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|
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|
|
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|