Annual report pursuant to Section 13 and 15(d)

STOCK-BASED COMPENSATION - Employee Stock Option Plans (Details)

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STOCK-BASED COMPENSATION - Employee Stock Option Plans (Details)
 12 Months Ended
Dec. 31, 2016
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Dec. 31, 2016
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Dec. 31, 2016
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Dec. 31, 2016
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Dec. 31, 2016
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STOCK-BASED COMPENSATION          
Number of stock option plans   4 4    
Employee stock option          
STOCK-BASED COMPENSATION          
Expiration period 10 years        
Number of shares of common stock authorized (in shares) 26,805,929 26,805,929 26,805,929 26,805,929 26,805,929
Options exercised during the period (in shares)         336,520
Equity incentive plan 2011 | Employee stock option          
STOCK-BASED COMPENSATION          
Number of shares of common stock authorized (in shares) 12,678,697 12,678,697 12,678,697 12,678,697 12,678,697
Options exercised during the period (in shares)         335,895
Equity incentive plan 2011 | Employee stock option | Minimum          
STOCK-BASED COMPENSATION          
Vesting period 0 years        
Equity incentive plan 2011 | Employee stock option | Maximum          
STOCK-BASED COMPENSATION          
Expiration period 10 years        
Vesting period 5 years        
Equity incentive plan 2000 | Employee stock option          
STOCK-BASED COMPENSATION          
Number of shares of common stock authorized (in shares) 12,299,050 12,299,050 12,299,050 12,299,050 12,299,050
Options exercised during the period (in shares)         625
Equity incentive plan 2000 | Employee stock option | Minimum          
STOCK-BASED COMPENSATION          
Vesting period 0 years        
Equity incentive plan 2000 | Employee stock option | Maximum          
STOCK-BASED COMPENSATION          
Vesting period 5 years        
Non-employee directors stock option plan 2000 | Employee stock option          
STOCK-BASED COMPENSATION          
Number of shares of common stock authorized (in shares) 1,188,182 1,188,182 1,188,182 1,188,182 1,188,182
Options exercised during the period (in shares)         0
Non-employee directors stock option plan 2000 | Employee stock option | Maximum          
STOCK-BASED COMPENSATION          
Expiration period 10 years        
Inducement Plan          
STOCK-BASED COMPENSATION          
Number of shares of common stock authorized (in shares) 640,000 640,000 640,000 640,000 640,000
Inducement Plan | Employee stock option          
STOCK-BASED COMPENSATION          
Options exercised during the period (in shares)         0
Inducement Plan | Employee stock option | Maximum          
STOCK-BASED COMPENSATION          
Expiration period 10 years        
Employee stock purchase plan          
STOCK-BASED COMPENSATION          
Strike price as a percentage of fair value of common stock       85.00%  
Number of shares of common stock authorized 2,518,870 2,518,870 2,518,870 2,518,870 2,518,870