Annual report pursuant to Section 13 and 15(d)

STATEMENTS OF OPERATIONS

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STATEMENTS OF OPERATIONS - USD ($)
shares in Thousands, $ in Thousands
12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Total revenues $ 149,236 $ 108,621 $ 59,288
Costs and expenses:      
Cost of product sales 1,083 895 906
Research and development 65,237 60,101 52,885
Selling, general and administrative 91,891 76,598 74,588
Restructuring charges 3,521    
Total costs and expenses 161,732 137,594 128,379
Loss from operations (12,496) (28,973) (69,091)
Interest income 47 582 2,532
Interest expense (4,860) (1,353) (335)
Loss before income taxes (17,309) (29,744) (66,894)
Provision for income taxes 605    
Net loss $ (17,914) $ (29,744) $ (66,894)
Net loss per share, basic and diluted      
Basic (in dollars per share) $ (0.11) $ (0.18) $ (0.40)
Diluted (in dollars per share) $ (0.11) $ (0.18) $ (0.40)
Weighted average shares used in computing net loss per share, basic and diluted      
Basic (in shares) 170,492 168,754 167,400
Diluted (in shares) 170,492 168,754 167,400
Product sales, net      
Total revenues $ 63,010 $ 61,696 $ 43,772
Contract revenues from collaborations      
Total revenues 75,726 $ 46,925 $ 15,516
Government contract      
Total revenues $ 10,500