Annual report pursuant to Section 13 and 15(d)

INCOME TAXES (Tables)

v3.22.0.1
INCOME TAXES (Tables)
12 Months Ended
Dec. 31, 2021
INCOME TAXES  
Schedule of components of the entity's deferred tax assets

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December 31,

 

​

    

2021

    

2020

 

Deferred tax assets

​

​

​

​

​

​

​

Net operating loss carryforwards

​

$

229,364

​

$

240,767

​

Orphan drug and research and development credits

​

 

66,616

​

 

64,252

​

Deferred compensation

​

 

8,819

​

 

7,760

​

Lease liabilities

​

​

2,564

​

​

4,399

​

Capitalized inventory

​

​

47

​

​

34

​

Deferred revenue

​

 

16,297

​

 

1,405

​

Other, net

​

 

1,626

​

 

1,765

​

Deferred tax liabilities

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​

​

​

​

​

​

Operating lease right-of-use asset

​

​

(2,335)

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​

(4,084)

​

Others

​

​

(607)

​

​

(537)

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Total net deferred tax assets

​

​

322,391

​

​

315,761

​

Less: valuation allowance

​

 

(322,391)

​

 

(315,761)

​

Deferred tax assets, net of allowance

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$

—

​

$

—

​

Schedule of reconciliation of the statutory federal income tax rate to the effective tax rate

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Year Ended December 31,

 

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2021

    

2020

    

2019

 

Federal statutory tax rate

 

(21.0)

%  

(21.0)

%  

(21.0)

%

State, Net of Federal Benefit

​

2.8

%  

0.1

%  

0.1

%

Valuation allowance

 

27.5

%  

24.4

%  

21.7

%

Stock compensation

​

5.6

%  

4.7

%  

2.8

%

Orphan drug and research and development credits

​

(14.0)

%  

(12.7)

%  

(5.1)

%

Other, net

 

2.7

%  

4.6

%  

1.5

%  

Effective tax rate

 

3.6

%  

0.1

%  

0.0

%  

Schedule of activity related to the entity's gross unrecognized tax benefits

The following table summarizes the activity related to our gross unrecognized tax benefits (in thousands):

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Year Ended December 31,

 

​

    

2021

    

2020

    

2019

 

Balance at the beginning of the year

​

$

8,901

​

$

8,358

​

$

8,358

​

Increase related to current year tax positions

​

 

285

​

 

543

​

 

543

​

Balance at the end of the year

​

$

9,186

​

$

8,901

​

$

8,358

​