Annual report pursuant to Section 13 and 15(d)

STOCK-BASED COMPENSATION (Details)

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STOCK-BASED COMPENSATION (Details)
1 Months Ended 12 Months Ended
Sep. 30, 2016
employee
Dec. 31, 2016
USD ($)
Dec. 31, 2015
USD ($)
Dec. 31, 2014
USD ($)
Stock-based compensation expense related to stock-based awards        
Total stock-based compensation expense   $ 7,832,000 $ 7,403,000 $ 9,787,000
Number of positions eliminated | employee 46      
General and administrative        
Stock-based compensation expense related to stock-based awards        
Total stock-based compensation expense   4,230,000 3,303,000 5,113,000
Incremental stock-based compensation expense       1,500,000
Research and development        
Stock-based compensation expense related to stock-based awards        
Total stock-based compensation expense   3,103,000 $ 4,100,000 $ 4,674,000
Incremental stock-based compensation expense   641,000    
Restructuring charge        
Stock-based compensation expense related to stock-based awards        
Total stock-based compensation expense   499,000    
Incremental stock-based compensation expense   $ 499,000