Annual report pursuant to Section 13 and 15(d)

PROPERTY AND EQUIPMENT (Details)

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PROPERTY AND EQUIPMENT (Details) - USD ($)
12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
PROPERTY AND EQUIPMENT      
Total property and equipment $ 19,948,000 $ 19,763,000  
Less accumulated depreciation and amortization (18,792,000) (18,150,000)  
Property and equipment, net 1,156,000 1,613,000  
Assets disposed 618,000 6,500,000  
Depreciation and amortization 941,000 1,439,000 $ 2,359,000
Restructuring, asset impairment charges 319,000    
Laboratory equipment      
PROPERTY AND EQUIPMENT      
Total property and equipment 17,986,000 17,892,000  
Computer and software      
PROPERTY AND EQUIPMENT      
Total property and equipment 1,280,000 1,189,000  
Furniture and equipment      
PROPERTY AND EQUIPMENT      
Total property and equipment $ 682,000 $ 682,000