Annual report pursuant to Section 13 and 15(d)

STATEMENTS OF STOCKHOLDERS' EQUITY

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STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($)
$ in Thousands
Common stock
Additional Paid-in Capital
Accumulated Other Comprehensive Income (Loss)
Accumulated Deficit
Total
Balance at Dec. 31, 2016 $ 100 $ 1,115,807 $ (18) $ (1,060,862) $ 55,027
Balance (in shares) at Dec. 31, 2016 99,269,418        
Increase (Decrease) in Stockholders' Equity          
Net loss       (77,992) (77,992)
Net change in unrealized gain (loss) on short-term investments     (64)   (64)
Issuance of common stock upon exercise of options and participation in Purchase Plan $ 1 3,507     3,508
Issuance of common stock upon exercise of options and participation in Purchase Plan (in shares) 1,564,395        
Issuance of common stock, net of offering costs $ 46 114,134     114,180
Issuance of common stock, net of offering costs (in shares) 45,981,093        
Stock compensation expense   5,987     5,987
Balance at Dec. 31, 2017 $ 147 1,239,435 (82) (1,138,854) 100,646
Balance (in shares) at Dec. 31, 2017 146,814,906        
Increase (Decrease) in Stockholders' Equity          
Net loss       (70,480) (70,480)
Net change in unrealized gain (loss) on short-term investments     58   58
Issuance of common stock upon exercise of options and participation in Purchase Plan $ 2 4,730     4,732
Issuance of common stock upon exercise of options and participation in Purchase Plan (in shares) 1,956,599        
Issuance of common stock, net of offering costs $ 18 67,144     67,162
Issuance of common stock, net of offering costs (in shares) 18,400,000        
Stock compensation expense   7,759     7,759
Balance at Dec. 31, 2018 $ 167 1,319,068 (24) (1,209,334) 109,877
Balance (in shares) at Dec. 31, 2018 167,171,505        
Increase (Decrease) in Stockholders' Equity          
Net loss       (66,894) (66,894)
Net change in unrealized gain (loss) on short-term investments     47   47
Issuance of common stock upon exercise of options and participation in Purchase Plan $ 1 1,575     1,576
Issuance of common stock upon exercise of options and participation in Purchase Plan (in shares) 816,345        
Stock compensation expense   9,209     9,209
Balance at Dec. 31, 2019 $ 168 $ 1,329,852 $ 23 $ (1,276,228) $ 53,815
Balance (in shares) at Dec. 31, 2019 167,987,850