Quarterly report pursuant to Section 13 or 15(d)

Stock-based Compensation (Details)

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Stock-based Compensation (Details) - USD ($)
$ in Thousands
3 Months Ended 6 Months Ended
Jun. 30, 2015
Jun. 30, 2014
Jun. 30, 2015
Jun. 30, 2014
Stock-based compensation expense related to stock-based awards        
Total stock-based compensation expense $ 1,909 $ 2,132 $ 3,963 $ 4,496
Research and development        
Stock-based compensation expense related to stock-based awards        
Total stock-based compensation expense 1,056 1,189 2,216 2,503
General and administrative        
Stock-based compensation expense related to stock-based awards        
Total stock-based compensation expense $ 853 $ 943 $ 1,747 $ 1,993