This collaboration includes the co-development and co-commercialization of Rigel’s R552, a receptor-interacting serine/threonine-protein kinase 1 (RIPK1) inhibitor, for all indications including autoimmune and inflammatory diseases. Pursuant to the collaboration, Lilly will also lead all clinical development of brain penetrating RIPK1 inhibitors in central nervous system (CNS) diseases.

Rigel received an upfront payment and is eligible for development, regulatory, and commercial milestone payments, as well as tiered royalty payments on any future net sales of any products emerging from the collaboration.

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Development of R552:

  • In Q2 2023, the initial Phase 2a trial (NCT05848258) in approximately 100 patients with moderately to severely active rheumatoid arthritis (RA) was initiated by partner Eli Lilly.

Development of RIPK1 Inhibitors for CNS Diseases:

  • Lilly is solely responsible for all development and commercialization of brain penetrating RIPK1 inhibitors in CNS indications