In October 2019, Rigel entered into exclusive commercialization license agreements with Medison Pharma to commercialize fostamatinib disodium hexahydrate (fostamatinib) in all potential indications in Canada and Israel.

In November 2020, Rigel received approval from Health Canada for its new drug submission (NDS) for fostamatinib for the treatment of thrombocytopenia in adult patients with chronic immune thrombocytopenia (ITP) who have had an insufficient response to other treatments. The product launched in December 2020 and is marketed in Canada under the brand name TAVALISSE®. It is the first and only spleen tyrosine kinase (SYK) inhibitor approved in Canada for this indication.

In Israel, a new drug application (NDA) has been submitted for fostamatinib for the treatment of ITP in adult patients, with a response expected from Ministry of Health in Q3 2021.

Rigel received an upfront payment, which included an advanced royalty payment, and is eligible for regulatory and commercial milestone payments, as well as tiered royalty payments on any future net sales of any products emerging from the collaboration.