At Rigel Pharmaceuticals, we are dedicated to improving the lives of patients through the discovery, development, and commercialization of novel small molecule drugs.
In particular, we are focused on immune and hematologic disorders, cancer, and rare diseases. We see great opportunity to help patients who have diseases where few to no approved treatment options exist.
The company’s first FDA approved product is TAVALISSE® (fostamatinib disodium hexahydrate) tablets*, the only oral spleen tyrosine kinase (SYK) inhibitor for the treatment of adult patients with chronic immune thrombocytopenia (ITP) who have had an insufficient response to a previous treatment. ITP is a rare autoimmune disease where the body’s own immune system attacks and destroys platelets in the blood.
Our clinical programs include a Phase 3 study of TAVALISSE in warm antibody autoimmune hemolytic anemia (AIHA), a recently completed Phase 1 study of R835, an investigational molecule from our interleukin receptor associated kinase (IRAK) inhibitor program, and an ongoing Phase 1 study of R552, an investigational molecule from our receptor-interacting protein kinase (RIP1) inhibitor program.
In addition, Rigel continues to build an extensive portfolio of investigational agents, which are being developed with our partners. These products are focused on the inhibition of select signaling pathways, which includes the pathways for Axl tyrosine kinase (AXL), Janus kinase (JAK), and murine double minute 2 (MDM2). Through strategic partnerships and collaborations, we are able to take advantage of additional experience and resources, while benefitting from the potential success of these future products, both through milestone payments and royalties.
At Rigel, we are able to leverage our wealth of in-house talent and anticipate continued growth in our pipeline from ongoing pre-clinical efforts of our highly experienced research and development teams.